直播時間：2025年9月16日（周二）20:00-21:30
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北京時間9月16日晚八點，iCANX Youth Talks第115期邀請到了上海交通大學(xué)博士生李成棟、解放軍總醫(yī)院胡樹釬擔(dān)任主講嘉賓，上海交通大學(xué)副教授苗鵬、清華大學(xué)教授曹良才擔(dān)任研討嘉賓，解放軍總醫(yī)院第五醫(yī)學(xué)中心消化內(nèi)科主任劉巖擔(dān)任主持人，期待你一起加入這場知識盛宴。
【嘉賓介紹】
李成棟
上海交通大學(xué)
基于組織動態(tài)性單幀統(tǒng)計門控技術(shù)的消化內(nèi)鏡下腫瘤檢測
【Abstract】
The propagation of coherent light in dynamic disordered media generates dynamic speckle patterns, wherein the multiple scattering component with fast dynamics exhibits a shorter decorrelation time () than the single scattering component with slow dynamics (). We propose a single-frame statistical gating strategy that enables the statistical separation of these two components using only a single image in reflective wide-field imaging when the exposure time satisfies . This method models the spatial matrix as the sum of a negative exponential matrix (representing single scattering) and a Gaussian matrix (representing multiple scattering), and utilizes the Marchenko–Pastur distribution and the Tracy-Widom distribution to calculate the moments of each component. The effectiveness of this method was validated through dynamic electric field Monte Carlo simulations and in vivo brain imaging experiments. Based on rotational invariance, we further proposed a rotational sampling strategy, which significantly enhances the imaging quality.
In clinical applications, we applied the single-frame statistical gating strategy to the early detection of gastrointestinal cancers. This technique differentiates malignant tumors from normal tissue by analyzing differences in tissue dynamics from a single image frame. In a clinical study involving 21 patients (including 5 with malignant tumors), the method achieved an AUC of 0.91 in receiver operating characteristic (ROC) analysis, and provided up to a 24.8-fold improvement in imaging contrast compared to conventional white light imaging. We applied the general-purpose segmentation model SAM to the dynamic indicator parameter (DIP) maps, which yielded excellent segmentation performance. This computational technique significantly enhances tissue contrast and tumor demarcation without the need for hardware modifications or exogenous contrast agents. Its plug-and-play nature allows for seamless integration into existing digestive endoscopy systems, promising broad clinical applicability.
相干光在動態(tài)無序介質(zhì)中傳播會產(chǎn)生動態(tài)散斑圖案，其中具有快速動態(tài)特性的多次散射成分的去相關(guān)時間會短于具有慢速動態(tài)特性的單次散射成分。我們提出一種單幀統(tǒng)計門控策略，能夠在曝光時間滿足的反射式寬場成像中僅使用單幀圖像實現(xiàn)二者的統(tǒng)計分離。該方法將空間矩陣建模為負指數(shù)矩陣（代表單次散射）和高斯矩陣（代表多次散射）的疊加，并利用Marchenko–Pastur分布和Tracy–Widom分布計算各成分的矩。通過動態(tài)電場蒙特卡洛模擬和活體腦成像實驗驗證了該方法的有效性?；谛D(zhuǎn)不變性，我們進一步提出旋轉(zhuǎn)采樣策略，顯著提升成像質(zhì)量。
在臨床應(yīng)用中，我們將單幀統(tǒng)計門控策略應(yīng)用于胃腸道癌癥的早期檢測。該方法通過單幀圖像分析組織動態(tài)性差異，從而區(qū)分惡性腫瘤與正常組織。在一項包含21例患者（其中5例為惡性腫瘤）的臨床研究中，該方法在ROC分析中AUC達到0.91，成像對比度較傳統(tǒng)白光成像提升24.8倍。我們將通用分割大模型SAM應(yīng)用于動態(tài)性參數(shù)DIP圖實現(xiàn)了優(yōu)秀的分割性能。該計算技術(shù)無需硬件改造或外源性對比劑即可顯著提升組織對比與腫瘤邊界識別能力，可無縫集成于現(xiàn)有消化內(nèi)鏡系統(tǒng)，具有廣泛的臨床適用性。
【BIOGRAPHY】
Li Chengdong, a Ph.D. candidate at the School of Biomedical Engineering, Shanghai Jiao Tong University. Li Chengdong received the Bachelors degree from Beihang University in June 2021. Research Direction: Statistical gating mechanisms in matrix optics wide-field imaging and its application in digestive endoscopy imaging. His related work has been published in Applied Physics Letters, and he delivered an oral presentation at the 2025 China Biomedical Engineering Conference and Innovative Medical Summit.
李成棟，上海交通大學(xué)生物醫(yī)學(xué)工程學(xué)院在讀博士生，2021年6月獲北京航空航天大學(xué)學(xué)士學(xué)位。研究方向：矩陣光學(xué)寬場成像中的統(tǒng)計門控機制及其消化內(nèi)鏡成像中的應(yīng)用。相關(guān)成果發(fā)表在Applied Physics Letters期刊，參加2025中國生物醫(yī)學(xué)工程大會暨創(chuàng)新醫(yī)療峰會并作口頭匯報。
胡樹釬
解放軍總醫(yī)院
破局·新生：消化道早癌內(nèi)鏡下全鏈條診療微創(chuàng)新
【ABSTRACT】
Gastrointestinal (GI) malignancies remain among the leading contributors to the global cancer burden. For early lesions, being seen early, and being treated well is pivotal to reducing mortality and healthcare costs. This lecture will present our team’s end-to-end innovations in diagnosis and therapy, including: (1) on the foundation of multimodal endoscopy, we have validated and quantified the diagnostic performance of Linked Color Imaging for early GI cancer, contributing to consensus building and standardization. We further developed and implemented a data-gated imaging framework to enhance recognition and thereby improve diagnostic accuracy; (2) under rigorous risk control, we explored a judicious extension of indications and upgrades in technical pathways, while iteratively engineering in-house devices—namely, a novel endoscopic metal clip and an intestinal protection device—to strengthen tissue closure, streamline procedural efficiency, and improve postoperative outcomes; and (3) we initiated an integrated post-resection specimen processing paradigm by establishing a point-to-point endoscopist–pathologist workflow, yielding a learnable data feedback loop. Overall, we aim to delineate a pathway from technological innovation to real-world clinical value, providing a feasible paradigm for the scalable and reproducible dissemination of early detection and early treatment.
消化道腫瘤長期位居全球腫瘤負擔(dān)前列，早期病變“看得見、看得早、治得好”是降低死亡率與醫(yī)療負擔(dān)的關(guān)鍵。本次演講將系統(tǒng)呈現(xiàn)我們團隊在“全鏈條”診療上的探索與實踐，內(nèi)容包括：（1）在窄帶/染色等多模態(tài)基礎(chǔ)上，我們驗證并量化了聯(lián)動成像對早癌的診斷效能，推動形成規(guī)范化共識，進一步合作實踐數(shù)據(jù)門控成像，實現(xiàn)對難辨病灶的增強識別，提升早癌診斷能力；（2）在嚴(yán)格風(fēng)險控制下，探索適應(yīng)證的合理外延與技術(shù)路徑升級，同步迭代自研器械——內(nèi)鏡下新型金屬夾與腸道保護裝置，以提升閉合強度、流程效率與術(shù)后結(jié)局；（3）開創(chuàng)術(shù)后標(biāo)本一體化處理的新理念，建立“內(nèi)鏡醫(yī)生—病理醫(yī)生”點對點聯(lián)動流程，形成可學(xué)習(xí)的數(shù)據(jù)閉環(huán)。本報告力圖展示一條由技術(shù)創(chuàng)新走向臨床價值落地的路徑，為“早診早治”的可復(fù)制推廣提供可行范式。
【BIOGRAPHY】
Education
2018–2023 B.S., Clinical Medicine, School of Medicine, Nankai University
2023–present M.S. Candidate in Gastroenterology, Joint Program of PLA General Hospital and Nankai University
Research Interest
Clinical translational application of novel endoscopic suturing techniques in gastroenterology
學(xué)習(xí)經(jīng)歷：
2018—2023 南開大學(xué)醫(yī)學(xué)院 臨床醫(yī)學(xué) 學(xué)士
2023— 今 解放軍總醫(yī)院與南開大學(xué)聯(lián)合培養(yǎng) 消化內(nèi)科 碩士在讀
研究方向：
消化內(nèi)鏡下新型縫合技術(shù)的臨床轉(zhuǎn)化應(yīng)用
【主持人】
劉巖
解放軍總醫(yī)院
【研討嘉賓】
苗鵬
上海交通大學(xué)
曹良才
清華大學(xué)
本文鏈接：上海交通大學(xué)、解放軍總醫(yī)院兩位專家講述消化道早癌檢測與創(chuàng)新http://www.sq15.cn/show-11-26019-0.html
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